Software for Interactive Musculoskeletal Modeling (SIMM) 4.1.1 (c) MusculoGraphics, Inc. *Dongle Emulator (Dongle Crack) for KeyLok II*

Software for Interactive Musculoskeletal Modeling (SIMM) 4.1.1 (c) MusculoGraphics, Inc. *Dongle Emulator (Dongle Crack) for KeyLok II* SIMM and OpenSim 5.0

SIMM is a widely used software system for modeling the musculoskeletal system. OpenSim, a free application with complementary capabilities, has recently been introduced. Together, these two software systems offer biomechanics researchers unsurpassed capabilities for modeling and simulation of the musculoskeletal system. The purpose of this technical note is to clarify the complementary nature of SIMM and OpenSim.


SIMM was introduced in the early 1990s and has become adopted by the biomechanics community. This software is now used by hundreds of biomechanics researchers to create computer models of musculoskeletal structures and to simulate movements such as walking, cycling, running, and stair climbing. Using SIMM, models of the lower and upper extremities were developed to examine the biomechanical consequences of surgical procedures including tendon surgeries, osteotomies and total joint replacements. A lower-extremity model was used to estimate muscle-tendon lengths, velocities, moment arms, and induced accelerations during normal and pathologic gait. Studies have been conducted to investigate the treatment of individuals with spinal cord injury, to analyze joint mechanics in subjects with patellofemoral pain, to calculate forces at the knee during running and cutting, and to investigate causes of abnormal gait. SIMM has helped bring simulation to biologists who have created computational models of the frog, tyrannosaur, cockroach, and other animals. The articles that describe SIMM and SIMM models [1-3] have been cited hundreds of times in the scientific literature. Version 5.0 of SIMM was released in February 2010, and includes new features designed to aid clinical gait analysis, such as batch-processing capabilities, calculation of heel strike and toe off events, averaging of multiple trials, and AVI movie output. Although SIMM helps formulate models of the musculoskeletal system and create dynamic simulations of movement, it has relatively limited tools for computing muscle excitations that produce coordinated movement and for analyzing the results of dynamic simulations. These complementary capabilities are provided by OpenSim.


OpenSim is an open-source software system that lets users create and analyze dynamic simulations of movement [4]. It is being developed at Simbios, a NIH center at Stanford University for physics-based simulation of biological structures. The underlying software is written in ANSI C++, and the graphical user interface is written in Java. Version 1.0 was released on August 22, 2007. Since then the software has been downloaded over 3,800 times. It contains modules that scale a generic musculoskeletal model to fit a specific subject, fit the model to recorded marker data (inverse kinematics), perform inverse dynamics, and generate muscle-driven forward simulations from recorded gait data. OpenSim can import and export most SIMM models. It contains a muscle editor, model viewer, coordinate viewer, and plotting tool, but no other model editing tools (e.g., there is no joint editor, body editor, wrap editor, marker editor, deform editor, or constraint editor). Version 2.0 was released in January 2010, and includes contact modeling, static optimization to estimate muscle and joint forces, and an application programmerís interface (API) that enables software developers to call OpenSim functions from their own programs or MATLAB.

Using OpenSim and SIMM together

Because OpenSim can import and export SIMM models, users can easily take advantage of features in each package. They can import their SIMM models and motion data into OpenSim, perform residual reduction and computed muscle control analyses, and export the results back to SIMM. Here is the recommended process for importing data into OpenSim to create subject-specific, muscle-driven simulations of gait data:

1. Develop the generic (unscaled) musculoskeletal model in SIMM, or modify or use an existing SIMM model
2. Convert motion data into the OpenSim format using SIMMís Motion Module, C3D Module, or the OpenSMAC utility program
3. Import the generic SIMM model into OpenSim
4. Load the motion data into OpenSim, for use by the scaling and IK tools
5. Run the residual reduction algorithm (RRA)
6. Run the computed muscle control analysis (CMC)

If users want to modify muscle properties and run additional simulations, they can do this in OpenSim. If they want to make other changes to the model, they should load their model into SIMM for editing, then re-import it into OpenSim.

OpenSim Benefits

The main benefits of OpenSim 2.0 over SIMM 5.0 are that it:

1. has a more full-featured model scaling utility (e.g., can require that left and right sides be of equal size)
2. has a more full-featured inverse kinematics utility (e.g., can explicitly specify some joint angles while using markers to track others)
3. contains ""residual reduction algorithm"" to make recorded motion data more dynamically consistent with recorded ground reaction forces, resulting in more accurate inverse dynamics results
4. can generate muscle-driven forward dynamic simulations that reproduce recorded gait data (using computed muscle control algorithm)
5. can perform dynamic simulations without SD/FAST or a C compiler
6. has more extensive analysis features for dynamic simulations
7. provides an API so OpenSim functions can be called from MATLAB and user-developed software

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